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KMID : 0043319980210020207
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Archives of Pharmacal Research
1998 Volume.21 No. 2 p.207 ~ p.211
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Prolyl Endopeptidase Inhibitors from Caryophylli Flos
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Lee Kyung-Hee
Kwak Jong-Hwan
Lee Kyung-Bok
Song Kyung-Sik
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Abstract
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Three prolyl endopeptidase inhibitors were isolated and identified as luteolin, quercetin and -sitosterol-3-O--D-glucopyranoside with of 0.17, 0.19 and 27.5 ppm, respectively. The inhibition of two flavonoids were non-competitive with substrate. Twenty authentic flavonoids were tested in order to investigate structure-activity relationship. No significant relationship was found in them, however, catechol moiety of B-ring and 7-OH group in flavonoid skeleton were seemed to be responsible for the stronger activity.
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KEYWORD
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Prolyl endopeptidase inhibitor, Eugenia caryophyllate, Caryophylli Flos, Luteolin, Quercetic, Flavonoids, β-sitosterol-3-O-β-D-glucopyranoside
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